| School | FirstYear | LastYear | Comment |
| Abbeville | 1960 | current | |
| AC Flora | 1960 | current | |
| Academic Magnet | 1998 | current | School created in 1998 as a magnet school in Charleston County for academically gifted schools |
| Aiken | 1960 | current | |
| Airport | 1965 | current | Opened in 1964 to handle overcrowding at Brookland Cayce |
| Allendale Fairfax | 1960 | current | |
| Anderson | 1960 | 1969 | Known as Anderson's Boy High, Later broken into TL Hanna and Westside |
| Andrew Jackson | 1969 | current | |
| Andrews | 1960 | current | |
| Ashwood Central | 1978 | 1980 | |
| Aynor | 1960 | current | |
| Bamberg | 1961 | 1964 | |
| Bamberg Ehrhardt | 1965 | current | |
| Baptist Hill | 1971 | current | |
| Barnwell | 1960 | current | |
| Baron DeKalb | 1976 | 1977 | |
| Batesburg Leesville | 1960 | current | |
| Battery Creek | 1973 | current | |
| Battery Park | 1972 | 1982 | |
| Beaufort | 1960 | current | |
| Bells | 1960 | 1971 | |
| Belton | 1960 | 1965 | |
| Belton Honea Path | 1966 | current | Opened with conolidation of Belton and Honea Path High Schools |
| Ben Lippen | 1994 | 1997 | Joined SCISA |
| Bennettsville | 1960 | 1987 | Closed along with 7 county school, Consolidated into Marlboro County High School |
| Berea | 1962 | current | |
| Berkeley | 1960 | current | |
| Bethune | 1960 | 1998 | |
| Bishop England | 1960 | current | |
| Bishopville | 1960 | 1999 | Closed with the consolidation of Marlboro County High Schools |
| Blacksburg | 1960 | current | |
| Blackville | 1962 | 1964 | |
| Blackville Hilda | 1960 | current | |
| Blenheim | 1970 | 1987 | Closed along with 7 county school, Consolidated into Marlboro County High School |
| Blue Ridge | 1960 | current | |
| Bluffton | 1960 | 1964 | |
| Blythewood (OLD) | 1960 | 1969 | |
| Boiling Springs | 1960 | current | |
| Bonds Wilson | 1970 | 1983 | |
| Bowman | 1960 | 2005 | Closed with consolidation of Bowman and Beaufort |
| Branchville | 1960 | 1992 | Dropped varsity football |
| Brookland Cayce | 1960 | current | |
| Broome | 1976 | current | Consolidation of Cowpens and Pacolet |
| BT Washington | 1970 | 1973 | |
| Buford | 1960 | current | |
| Burke | 1970 | current | |
| Butler | 1970 | 1981 | |
| Byrnes | 1960 | current | |
| CA Brown | 1970 | 1981 | |
| CA Johnson | 1970 | current | |
| Cades Hebron | 1971 | 1982 | |
| Cainhoy | 1970 | 1995 | |
| Calhoun County | 1982 | current | |
| Calhoun Falls | 1960 | current | |
| Camden | 1960 | current | |
| Cameron | 1960 | 1967 | |
| Cardinal Newman | 1962 | 1989 | Joined SCISA |
| Carolina | 1960 | current | |
| Carolina Forest | 1998 | current | Opened to alleviate overcrowding at Conway |
| Carvers Bay | 2000 | current | |
| CE Murray | 1973 | current | |
| Chapin | 1960 | current | |
| Chapman | 1960 | current | |
| Charleston | 1961 | 1982 | |
| Cheraw | 1960 | current | |
| Chesnee | 1960 | current | |
| Chester | 1960 | current | |
| Chesterfield | 1960 | current | |
| Chicora | 1960 | 1979 | |
| Choppee | 1972 | 1999 | |
| Christ Church | 1975 | current | |
| Clinton | 1960 | current | |
| Clio | 1960 | 1987 | Closed along with 7 county school, Consolidated into Marlboro County High School |
| Clover | 1960 | current | |
| Colleton County | 2002 | current | School formed as a consolidated county high school, students from Ruffin and Walterboro |
| Columbia | 1960 | current | |
| Conway | 1960 | current | |
| Cooper River | | | |
| Cowpens | 1960 | 1975 | Closed and consolidated with Pacolet to form Broome High School in eastern Spartanburg County |
| Creek Bridge | 2002 | current | |
| Crescent | 1960 | current | |
| Crestwood | 1996 | current | Reorganization of Sumter County Schools |
| Cross | 1960 | current | |
| Dacusville | 1960 | 1970 | |
| Daniel | 1960 | current | |
| Darlington | 1960 | current | |
| Denmark Olar | 1960 | current | |
| Dentsville | 1960 | 1969 | |
| Dillon | 1960 | current | |
| Dixie | 1960 | current | |
| Dorman | 1964 | current | Opened with consolidation of Fairforest, Roebuck and Lincoln school in District 6 Spartanburg |
| Dreher | 1960 | current | |
| Dutch Fork | 1992 | current | Opened to alleviate overcrowding at Irmo |
| Easley | 1960 | current | |
| East Clarendon | 1960 | current | |
| Eastside | 1970 | current | |
| Eau Claire | 1960 | current | |
| Edgefield | 1960 | 1960 | Closed along with Johnston to consolidate and form Strom Thurmond |
| Edisto | 1960 | current | |
| Ellen Woodside | 1960 | 1964 | |
| Elloree | 1960 | 2003 | Closed to form Lake Marion with Holly Hill Roberts |
| Emerald | 1994 | current | Opened to allevaite overcrowding at Greenwood |
| Estill | 1960 | current | |
| Fairfield Central | 1986 | current | |
| Fairforest | 1960 | 1963 | Closed when Spartanburg District 5 consolidated high schools |
| Flat Creek | 1960 | 1968 | |
| Florence | 1960 | 1974 | |
| Ford | 1960 | 1971 | Closed, students to Laurens |
| Fort Dorchester | 1992 | current | Opened to alleviate overcrowding at Summerville |
| Fort Johnson | 1970 | 1981 | |
| Fort Mill | 1960 | current | |
| Fox Creek | 2006 | current | New charter school located in Edgefield County |
| Furman | 1960 | 1995 | Closed during the reorg of Sumter County Schools |
| Gaffney | 1960 | current | |
| Garrett | 1960 | current | |
| Georgetown | 1960 | current | |
| Gilbert | 1972 | current | |
| Goose Creek | 1967 | current | |
| Graniteville | 1960 | 1979 | |
| Great Falls | 1960 | current | |
| Greeleyville | 1960 | 1969 | |
| Green Sea Floyds | 1960 | current | |
| Greenville | 1960 | current | |
| Greenwood | 1960 | current | |
| Greer | 1960 | current | |
| Hampton | 1960 | current | |
| Hanahan | 1960 | current | |
| Hannah Pamplico | 1960 | current | |
| Hardeeville (OLD) | 1964 | 1969 | |
| Harleyville Ridgeville | 1960 | 1998 | |
| Hartsville | 1960 | current | |
| Heath Springs | 1960 | 1968 | |
| Hemingway | 1960 | current | |
| Hickory Tavern | 1960 | 1971 | Closed, students to Laurens |
| Hillcrest Dalzell | 1960 | 1996 | Closed during the reorg of Sumter County Schools |
| Hillcrest Simpsonville | 1960 | current | |
| Hilton Head | 1983 | current | |
| Holly Hill | 1960 | 1980 | |
| Holly Hill Roberts | 1981 | 2003 | Closed to form Lake Marion with Ellorre |
| Honea Path | 1960 | 1965 | School Closed, Students with Belton to form Belton Honea Path |
| Hopkins | 1970 | 1970 | Afro American School cons. with Lower Richland |
| Howard | 1970 | 1981 | |
| Hunter Kinard Tyler | 1969 | current | |
| Indian Land | 1960 | current | |
| Irmo | 1960 | current | |
| Jackson | 1960 | 1980 | |
| James Island | 1960 | current | |
| Jasper County | 1986 | 2006 | Closed in 2006 with reorg of county school system |
| Jefferson | 1960 | 1968 | |
| JL Mann | 1965 | current | |
| Johnsonville | 1960 | current | |
| Johnston | 1960 | 1960 | Closed along with Edgefield to consolidate and form Strom Thurmond |
| Jonesville | 1960 | 2006 | Closed when Union County consolidated high schools |
| Keenan | 1970 | current | |
| Kershaw | 1960 | 1968 | |
| Kingstree | 1960 | current | |
| Lake City | 1960 | current | |
| Lake Marion | 2004 | current | New school consolidated from Elloree and Holly Hills |
| Lake View | 1961 | current | |
| Lakewood | 1996 | current | Reorganization of Sumter County Schools |
| Lamar | 1960 | current | |
| Lancaster | 1960 | current | |
| Landrum | 1960 | current | |
| Langley Bath Clearwater | 1960 | 1979 | |
| Latta | 1960 | current | |
| Laurens | 1960 | current | |
| Lee Central | 2000 | current | |
| Lewisville | 1960 | current | |
| Lexington | 1960 | current | |
| Liberty | 1960 | current | |
| Lincoln | 1970 | current | |
| Lockhart | 1960 | 1995 | Dropped SCHSL football, played independent until school closed in 2007 |
| Loris | 1960 | current | |
| Lower Marlboro | 1964 | 1969 | Closed, students to Blenheim then Marlboro County High in 1987 |
| Lower Richland | 1960 | current | |
| Lugoff Elgin | 1973 | current | |
| Macedonia | 1960 | 1995 | Closed, students with St Stephens to form Timberland |
| Manning | 1960 | current | |
| Marion | 1960 | current | |
| Marlboro County | 1988 | current | Consolidation of the 7 small county high schools |
| Mauldin | 1974 | current | |
| Mayewood | 1960 | 1995 | Closed during the reorg of Sumter County Schools |
| Mayo | 1970 | 1994 | |
| McBee | 1960 | current | |
| McClenaghan | | | |
| McColl | 1960 | 1987 | Closed along with 7 county school, Consolidated into Marlboro County High School |
| McCormick | 1960 | current | |
| McCracken | 1972 | 1982 | |
| McDuffie | 1971 | 1995 | Closed, students to Anderson schools |
| Mid Carolina | 1960 | current | |
| Middleton | 1971 | 1999 | Closed, students with St Andrews to form West Ashley |
| Midland Valley | 1980 | current | |
| Moultrie | 1960 | 1972 | |
| Mount Pisgah | 1960 | 1978 | |
| Mount Pleasant | 1970 | 1999 | |
| Mullins | 1960 | current | |
| Myrtle Beach | 1960 | current | |
| Newberry | 1960 | current | |
| Ninety Six | 1960 | current | |
| North | 1960 | current | |
| North Augusta | 1960 | current | |
| North Central | 1979 | current | |
| North Charleston | 1960 | current | |
| North Myrtle Beach | 1970 | current | |
| Northwestern | 1972 | current | |
| Norway | 1960 | 1968 | |
| Oakway | 1973 | 1981 | Closed when school consolidated with Westmsiter to form West Oak |
| Olanta | 1962 | 1973 | |
| Olympia | 1960 | 1969 | School Closed, studens to other Richland 1 schools |
| Orangeburg | 1960 | 1970 | Consolidated with Wilkinson to form Orangeburg Wilkinson |
| Orangeburg Wilkinson | 1971 | current | |
| Pacolet | 1960 | 1975 | Closed and consolidated with Cowpens to form Broome High School in eastern Spartanburg County |
| Pageland Central | 1960 | current | |
| Palmetto | 1960 | current | |
| Pamplico | 1961 | 1963 | |
| Parker | 1960 | 1984 | Closed with students dispersed to Berea and Greenville |
| Pelion | 1980 | current | |
| Pendleton | 1960 | current | |
| Pickens | 1960 | current | |
| Pleasant Hill | 1973 | 1999 | |
| Porter Gaud | 1965 | 1987 | Joined SCISA |
| Richland Northeast | 1978 | current | Opened to alleviate overcrowding at Spring Valley |
| Ridge Springs Monetta | 1960 | current | |
| Ridge View | 1996 | current | Opened to alleviate overcrowding at Spring Valley and RNE |
| Ridgeland | 1960 | 1985 | |
| Riverside | 1974 | current | |
| Roberts | 1970 | 1980 | |
| Rock Hill | 1960 | current | |
| Ruffin | 1972 | 2001 | Closed, students to Colleton County |
| Salley | 1964 | 1965 | |
| Saluda | 1960 | current | |
| Scotts Branch | 1970 | current | |
| SCSFD | 1966 | 1996 | Independent schedule |
| Seneca | 1960 | current | |
| Silver Bluff | 1981 | current | |
| Slater Marietta | 1960 | 1972 | Closed, students to Travelers Rest |
| Socastee | 1961 | current | |
| South Aiken | 1980 | current | Opened to alleviate overcrowding at Aiken |
| South Florence | 1975 | current | |
| Southside F | 1963 | 1974 | |
| Southside G | 1970 | current | |
| Spartanburg | 1960 | current | |
| Spartanburg Day | 1967 | 1967 | Dropped varsity football |
| Spaulding | 1971 | 1981 | |
| Spring Valley | 1970 | current | |
| Springfield | 1960 | 1968 | |
| St Andrews | 1960 | 1999 | Closed, students with Middleton to form West Ashley |
| St Angela | 1965 | 1983 | |
| St George | 1960 | 1998 | |
| St James | | current | |
| St Johns D | 1971 | 1994 | |
| St Johns JI | 1961 | current | |
| St Mark | 1972 | 1981 | |
| St Matthews | 1960 | 1981 | |
| St Pauls | 1961 | 1970 | |
| St Stephen | 1960 | 1995 | Closed, students with Macedonia to form St Stephens |
| Stall | 1960 | current | |
| Stratford | 1983 | current | |
| Strom Thurmond | 1961 | current | Opened with the consolidation of Johnston and Edgefield |
| Summerton | 1960 | 1969 | |
| Summerville | 1960 | current | |
| Sumter | 1960 | current | |
| Swansea | 1960 | current | |
| Terrells Bay | 1991 | 2001 | |
| Thornwell | 1960 | 2006 | The orphage that ran the school closed in 2006 |
| Timberland | 1996 | current | |
| Timmonsville | 1960 | current | |
| TL Hanna | 1970 | current | |
| Travelers Rest | 1960 | current | |
| Union | 1960 | current | |
| Waccamaw | 1991 | current | |
| Wagener | 1961 | 1964 | |
| Wagener Salley | 1960 | current | |
| Walhalla | 1960 | current | |
| Wallace | 1968 | 1987 | Closed along with 7 county school, Consolidated into Marlboro County High School |
| Walterboro | 1960 | 2001 | Closed with the consolidation of Walterboro and Ruffin |
| Wampee Little River | 1960 | 1969 | |
| Wando | 1973 | current | |
| Ware Shoals | 1960 | current | |
| West Ashley | 2000 | current | Opened as a result of the consolidation of Middleton and St. Andrews |
| West Florence | 1971 | current | |
| West Hardeeville | 1970 | 1985 | |
| West Oak | 1982 | current | Consolidation of Westminster and Oakway High Schools |
| Westminster | 1960 | 1981 | Closed and consolidated with Oakway to form West Oak |
| Westside | 1970 | current | |
| White Knoll | 2000 | current | Opened to alleviate overcrowding at Lexington |
| Whitmire | 1960 | current | |
| Wilkinson | 1970 | 1970 | Consolidated with Orangeburg to form Orangeburg Wilkinson |
| Williamsburg | 1960 | 1988 | |
| Williamsburg Blakely | 1970 | 1972 | |
| Williamsburg Training | | | |
| Williston Elko | 1960 | current | |
| Wilson | 1970 | current | |
| Winnsboro | 1960 | 1985 | |
| Winthrop Training | 1960 | 1964 | |
| Winyah | 1973 | 1981 | |
| Woodland | 2000 | current | |
| Woodmont | 1965 | current | |
| Woodruff | 1960 | current | |
| Wren | 1960 | current | |
| York | 1960 | current | |
| Blythewood | 2006 | current | Opened to alleviate overcrowding in Richland District 2. Students from Richland NE and Ridge View |
| South Pointe | 2006 | current | Opened to alleviate overcrowding in Rock Hill and Northwestern |
| Southside Christian | | | |
| Wade Hampton | 1961 | current | |
| Hardeeville | 2007 | current | Reorg of schools in Jasper County |
| Bethune Bowman | | | |
| Military Magnet | | | |
| Ridgeland | 2007 | current | Reorg of schools in Jasper County |
| Nations Ford | 2007 | current | Opened in 2007 as a split off from Fort Mill |
| Camden Military | | | |
| Carlisle Military | | | |
| Northside G | | | |
| Pageland | | | |
| Fairfield | | | |
| Olympia | | | |
| Taylors | | | |
| Paris | | | |
| Piedmont | | | |
| Cane Bay | 2008 | current | Opened in 2008 as a split from Stratford and Berkeley |
| Ashley Ridge | 2008 | current | Opened in 2008 as a split from Summerville and Fort Dorchester |